Aug 10, 2020
The second game in the 25th Anniversary series! Let's play and watch us explore a lost world where adventure and imagination truly do go hand-in-hand.
25th Anniversary Earth: You can't help but feel as if you've stumbled on a new world!
Aug 9, 2020
New Game, new challenges. An RPG style adventure game where you will have to explore the surface of a planet, to collect as many golden coins as possible!
Earth: Our future is uncertain but we must explore, study and learn... until the game's end.
Aug 8, 2020
The third game in the 25th Anniversary series! Let's play and watch us explore a lost world where adventure and imagination truly do go hand-in-hand.
25th Anniversary Earth: You can't help but feel as if you've stumbled on a new world!
Aug 5, 2020
The first game in the 25th Anniversary series! Let's play and watch us explore a lost world where adventure and imagination truly do go hand-in-hand.
25th Anniversary Earth: Welcome to your new world... and welcome to your first adventure!
Aug 4, 2020
Experience the power of the Dark Seer class in a FATE RPG where your actions will influence the outcome! The class opens up a lot of new gameplay possibilities!
The Dark Seer
Aug 1, 2020
Join us on Discord to play and watch!
Out of the chaos, the hopeful civilization of Earth has emerged. Even so, there is a dark force that tries to conquer the world. Do you have the courage to fight?
Aug 1, 2020
Join us on Discord to play and watch!
Out of the chaos, the hopeful civilization of Earth has emerged. Even so, there is a dark force that tries to conquer the world. Do you have the courage to fight?
July 31, 2020
Join us on Discord to play and watch!
Join us to watch a live stream of the new game show and play games.
A Show of Our Future
July 30, 2020
Join us on Discord to play and watch!
Join us to watch a live stream of the new game show and play games.
A Show of Our Future
July 28, 2020
Join us on Discord to play and watch!
Join us to watch a live stream of the new game show and 01e38acffe
programmer built indy game ship modelling and ship to ship cargo transfer 2018.
We provide large-scale computing resources with storage capacity ranging from a few gigabytes to several petabytes, which are used by academia and industry.
More than 50,000 simulation data from all over the world are managed using the distributed filesystem technology.
We provide a range of programmable resources that are used to develop software, test and debug software, create products, and deliver services.
We have also organized a range of training courses on the use of the computation resources, which are widely attended by scientists and engineers.
By organizing these courses, we hope to contribute to the education of the community.Neuroprotective effects of the antidepressant and antianxiety agent, venlafaxine, in a mouse model of Parkinson's disease.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor impairments. Mild cognitive impairment (MCI) occurs in approximately half of PD patients and progresses to dementia. Currently, there are no effective treatments to halt or reverse cognitive decline in PD. In the present study, we investigated whether the novel antidepressant and antianxiety drug, venlafaxine, a serotonin-norepinephrine reuptake inhibitor (SNRI), could be neuroprotective in an animal model of PD. Male C57BL/6 mice were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) for four consecutive days, and subsequently were treated with either vehicle or venlafaxine (20 mg/kg/day) for three weeks. The results indicate that treatment with venlafaxine significantly attenuated motor deficits in the MPTP-treated mice and rescued dopaminergic neurons from apoptotic death. This improvement in motor performance was associated with a significant increase in the activation of the Nrf2 antioxidant signaling pathway and a suppression of the JNK and p38MAPK stress-activated signaling pathways in the prefrontal cortex of the mice. However, the antidepressant effect of venlafaxine was not apparent. Together, these results suggest that venlafaxine could be a potential therapeutic agent for PD-related cognitive dysfunction and cognitive impairment.The role of hemodynamics and adipocytokines in the pathogenesis of angiographic progression in patients with coronary artery disease: a role for adipocytok
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